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Please select the option that best describes you:
Topics:
Breast Cancer
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Medical Oncology
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Breast Cancer, Metastatic
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HER+
Would you offer other antibody-drug conjugates to a patient who had a history of G2 trastuzumab deruxtecan-induced pneumonitis that is now resolved?
This includes TDM-1, datopotamab deruxtecan, and sacituzumab govitecan
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How do the findings from the INAVO120 trial influence your decision-making process for selecting subsequent lines of therapy in patients who have relapsed after adjuvant CDK4/6 inhibition?
In a patient with de novo stage IV breast carcinoma harboring an RB1 Q395* (nonsense) mutation, would treatment with a CDK4/6 inhibitor be appropriate, or should it be avoided due to likely resistance?
How, if at all, does the spectrum of HER2 positivity impact efficacy of T-DXd in the frontline setting?
How will you sequence Dato-DXd among available therapies for HR positive, HER2-0 metastatic breast cancer?
What treatment would you recommend for a patient with early-stage TNBC treated per KEYNOTE-522, PD-L1 CPS >10, with metastatic recurrence within 12 months of treatment completion?
For patients with HbA1c >6 can the INAVO regimen still be utilized if the patient is otherwise fit and has a strategy for ongoing glycemic control?
Would you add pertuzumab to adjuvant therapy for a premenopausal female with HR+, HER2+ IDC with N1mic disease?
How would you approach treatment selection for an elderly woman with de novo metastatic HER2+ breast cancer with lung and brain mets?
What supportive care measures do you prioritize to manage or prevent toxicity in patients receiving Dato-DXd?