Would you offer PMRT to a young woman with high-grade neuroendocrine carcinoma of the breast?  

The patient was treated with neoadjuvant cisplatin/etoposide followed by mastectomy and SLNB with a 4 cm primary and negative nodes. LVI was noted on pathology. 

What aspects of her case would make you more or less inclined to treated with PMRT? Would you treated CW and RNI comprehensively, or CW only? 



Answer from: Radiation Oncologist at Community Practice