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Would you offer radiation therapy to a patient with unresectable intracranial Rosai-Dorfman disease?

1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Toledo Clinic
Answered on

I recently treated a patient with this rare histiocytic entity. There is simply no consensus given its rarity. Having combed through PubMed and having read the relevant literature, most helpful was a guidelines article in Blood, which states that a reasonable approach for unresectable disease is 30-50 Gy in "lymphoma-like" schedule. My patient presented with de-facto spinal cord compression at T2, underwent R2 debulking, was started on prednisone, and received 36 Gy/20FX/1.8 Gy to the affected v...

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