Would you offer rituximab maintenance for 2 years after a successful response to induction in a patient with splenic marginal zone lymphoma?
When do you consider splenectomy? Is there a role for splenic radiation in non-surgical candidates?
Answer from: at Community Practice
Rituxan maintenance especially when done for 2 years versus 1 year can cause thrombocytopenia.
Also, patients with thrombocytopenia and mzl tend to have lower freedom from progression at 5 years (50% vs 75%).
IF your patient did not respond to Rituxan and has persistent thrombocytopenia, spl...
In what way would it depend on thrombocytopenia? ...