From my standpoint in sarcoma/connective tissue malignancies, I warmly agree with Dr. @Robert S. Malyapa. I actually have had a patient in nearly this same scenario... I treated him for a localized soft tissue sarcoma, and on staging he was incidentally found to have an unrelated esophageal GIST, wh...

I have personally never encountered this scenario. However, I would draw on the experience from nonresectable or metastatic gastric GIST and opt for the use of tyrosine kinase inhibitors. It would be important in the course of the management to pay attention to the nutritional requirements of the pa...