Would you offer RT for a low-grade esophageal GIST if the patient was not a surgical candidate?

From my standpoint in sarcoma/connective tissue malignancies, I warmly agree with Dr. @Dr. First Last. I actually have had a patient in nearly this same scenario... I treated him for a localized soft tissue sarcoma, and on staging he was incidentally found to have an unrelated esophageal GIST, which would have been resectable but only with significant morbidity. We treated the sarcoma with RT+ surgery and he went on a TKI for GIST and is doing fine. Most patients have good TKI options for GIST w...

I have personally never encountered this scenario. However, I would draw on the experience from nonresectable or metastatic gastric GIST and opt for the use of tyrosine kinase inhibitors. It would be important in the course of the management to pay attention to the nutritional requirements of the patient.