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Would you offer salvage radiation in a patient s/p radical prostatectomy with imaging showing local recurrence as well as oligometastatic disease in the pelvis?

Would you treat the entire pelvis vs local recurrence? How would you approach the oligometastatic lesion? Would your treatment recommendation change if the patient did not have radiographic evidence of local recurrence in the prostate bed? Assume the patient is initiating combined androgen suppression with GNRH-inhibitor and novel oral androgen-signaling inhibitor.
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Radiation Oncology · University of Texas Southwestern
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For oligonodal regional recurrence, I would treat the entire pelvic nodes and fossa and consider enrollment on RTOG 3506. If oligomet is to pelvic bone, I have rarely treated fossa/nodes/pelvic bone lesion (PET identified) in those wanting to be very aggressive and understanding the lack of data the...

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Radiation Oncology · UC San Diego
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I agree with @Dr. First Last. If the patient is N1M0, I will treat the pelvic nodes and the fossa. If the patient has confirmed distant metastases, I prefer to only treat gross disease and would not typically go after imaging-negative fossa or elective lymph nodes.

I completely agree that we need...

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Radiation Oncology · UCSF Medical Center-Mission Bay
Answered on

I agree with the sentiments above and will comment specifically about oligonodal recurrence alone.

I'd treat the entire pelvis, SIB the pelvic lymph node, and treat local recurrence if present supported by recent OLIGOPELVIS GETUG P07 data. The phase II trial examined the role of pelvic radiotherapy...

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Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on

For a patient with PSMA/MRI local recurrence + distant metastasis - I have a discussion with patients and if they want to be aggressive, given our understanding of oligometastatic prostate cancer, I would treat fossa, nodes, and metastasis simultaneously along with generally 2 years of ADT.

If no evi...

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