Would you offer surgery for an MSI-H pancreatic adenocarcinoma who had deep response to pembrolizumab?

This is a hard question. The 19-9 gives me pause (even with normalization) and I think most likely I would push on with checkpoint inhibitor therapy for a total of two years given that it is very unlikely surgery will clear disease and ICI may get you to a durable complete response on its own. I don...

I agree with Dr. LoConte. The patient has 2 scenarios: 1) Has obtained a deep and durable response (complete response): In this scenario, the addition of surgery is potentially only adding surgical and post-surgical complications. 2) Does not have complete response: The chances are that the disease ...