Would you offer upfront osimertinib rather than whole brain irradiation for a patient with stage IV, EGFR exon 19 mutated lung adenocarcinoma who presents with leptomeningeal metastases?

Topics: Thoracic Malignancies • Medical Oncology • NCI-CCC Tumor Board Question • Non-small cell lung cancer • University of Michigan

Answer from: Medical Oncologist at Community Practice

As always a challenging situation is raised by a question in this forum. Clearly more clinical information is relevant. Not clear as to what "The patient 'presented' with leptomeningeal metastases" means. In many patients, asymptomatic leptomeningeal metastases are detected on MRI scans of the ...

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