Would you offer XRT as bridging for all patients with limited pre CAR-T disease or as consolidation for only those with residual PET-avidity on day+30 post CAR-T?

Topics: Hematologic Malignancies • Radiation Oncology • Medical Oncology • Lymphoma • CAR-T • Hematology • ASTRO Journal Club

Answer from: Radiation Oncologist at Community Practice

There are no studies comparing these 2 approaches. However, given the detrimental outcomes of post CAR-T relapses, I would consider maximizing peri-CAR-T treatments as much as possible as long as the toxicity profile is reasonable, and would not view these 2 approaches as mutually exclusive. I would...

Comments

Medical Oncologist at University of Maryland Cancer Center
I would agree to use bridging (after collection) f...

Radiation Oncologist at Mayo Clinic College of Medicine and Science (Jacksonville)
There is only 20-30% rate of spontaneous conversio...

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