Would you perform an oncotype DX in a patient with a 0.5cm ER positive breast cancer with one lymph node positive for macrometastatic disease?
Answer from: Medical Oncologist at Community Practice
We published data from SEER in May of last year (Massarweh, JCO May 2018) looking at BCSS and OS in 55 thousand women with 0-3 lymph node involvement at 5 years. In patients with low and intermediate RS (up to 30) there is very little difference between node negative and node positive patients in te...
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Answer from: Medical Oncologist at Academic Institution
While I generally do not use gene profiling for node-positive breast cancer, I do think that the evidence points to diminished benefit from chemotherapy with lower gene profiling scores, with more evidence available from the 21-gene and 70-gene assays. However, at this point, the optimal cutpo...