Would you perform screening for pulmonary hypertension in a patient who has biopsy-proven Sjogren's but has a centromere antibody?   

Generally, the risk of pulmonary hypertension in Sjogren's is low - about 2% in a recent study using RHC for diagnosis (Coppi et al., PMID 40058609). There have been no studies linking Raynaud's to pulmonary hypertension risk in Sjogren's, although this is true in systemic sclerosis. So the real que...

In the big scheme of things, an Echo and PFT are easy to do to catch PAH early. Screening is also recommended in the Sjogren's treatment consensus published in 2021 (Lee et al., PMID 33075377).