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Would you provide abemaciclib to a premenopausal women with cT2 cN1 ER+ breast cancer and Ki67 of 80% who achieves pCR following neoadjuvant AC-T?

What would you offer a premenopausal woman with clinical T2N1 ER positive breast cancer for adjuvant therapy after she achieves a pathologic complete response to neoadjuvant AC-T? She meets the criteria for high risk disease per MonarchE given positive node + Ki67 of 80%.
1 Answer
Mednet Member
Mednet Member
Medical Oncology · Fort Sutter Med Onc/Hem
Answered on

Patients who received neoadjuvant Chemotherapy were only eligible for the trial if they had residual disease above a threshold quantified using CPS-EG.

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