Would you re-challenge a CLL patient, who had good response to Zanubrutinib but contracted cryptococcal pneumonia, with another BTK inhibitor?  

Infections are part of the natural history of CLL. While cryptococcal meningitis is the uncommon one in CLL, it does occur when these patients are on steroids, have prior receipt of fludarabine, bendamustine, or other treatments which suppress the cellular immune system (in particular CD4+ T-cells)....