Would you recommend a right hemicolectomy for a <1 cm low grade appendiceal goblet cell adenocarcinoma found incidentally during appendectomy without high risk features on pathology?

The simple answer is yes. Right hemicolectomy is recommended for appendiceal goblet cell adenocarcinoma (used to be called goblet cell carcinoid) regardless of disease stage or pathologic features as per the current guidelines from North American Neuroendocrine Tumor Society (NANETS) and the European Neuroendocrine Tumor Society (ENETS) (Boudreaux et al., PMID 20664473; Pape et al., PMID 22262080). The recommendations are based on the high risks of nodal metastases from this disease.

However, since this tumor is rare, no prospective study exploring this question has been done. Actually, there are severe retrospective studies that did not reveal any clear clinical benefits from a right hemicolectomy especially for patients with stage I disea...