Would you recommend a simultaneous integrated boost with hypofractionated whole breast radiation?

With the presentation of IMPORT HIGH trial (CRUK/06/003) at SABCS last month, the data for simultaneous integrated boost SIB in breast cancer is accumulating. This was a phase III trial that randomized 2,617 women to a sequential boost (50Gy +16Gy), SIB arm (40Gy to breast with 48 Gy to boost volume) and a higher SIB arm (40Gy to breast, 53Gy to boost volume). Median f/u 49 months. Of note, median age 49 (>50% of patients < age 50!), 30% node+, 66% received chemo. Rates of moderate/marked AEs at 3 years were similar between sequential and lower SIB arm but slightly increased in higher SIB arm.https://www.abstracts2view.com/sabcs18/view.php?nu=SABCS18L_527&terms=

There has been other non-randomized trial data, most notably the NYU data which ...