Would you recommend an allogenic stem cell transplant in an older patient > 50 with Ph negative acute lymphoblastic leukemia who is MRD negative after induction?

In general, I would not routinely recommend allogeneic hematopoietic cell transplantation (HCT) for Ph- acute lymphoblastic leukemia (ALL) that is in MRD-negative remission this early in their treatment. This sort of response demonstrates significant chemosensitivity. Therefore, I would favor contin...

Assuming that the patient has standard-risk disease, there is no clear consensus regarding the optimal consolidation therapy for these patients. Consolidation chemotherapy produces 4-year survival rates of ~50%. If ALL achieves MRD-negativity early on, I generally recommend chemotherapy alone, espec...