Would you recommend starting an SGLT2i in a patient with a kidney transplant and moderately increased albuminuria?
Would you recommend starting an SGLT2i in a patient with a kidney transplant and moderately increased albuminuria?
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I have used SGLT2i in my transplant patients to lower albuminuria either alone or in combination with RAASi. I do not use it in patients who have a Hx of frequent UTIs or who are at increased risk of developing UTIs (e.g. ileal conduit, neurogenic bladder, obstruction) due to the increased risk of urogenital infections. SGLT2i may be beneficial not only because of their kidney and cardiac benefits but also because they reduce the risk of new-onset diabetes.
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I have no trouble starting an SGLT2i in transplant recipients with moderately increased albuminuria as long as they do not have recurrent urinary tract infections. If started the patients should be monitored closely for UTI.
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