Would you recommend the addition of chemotherapy in a patient with locally recurrent, unresectable squamous cell carcinoma of the head and neck for whom repeat radiation is planned?

There is no standard of care in the setting of an unresectable, resistant local/regional recurrence after full dose RT and concurrent cisplatin. If the patient has a good PS, is medically fit, and the goal is a salvage cure, I would discuss adding a taxane to the planned RT. In an attempt to overcom...

This is a very challenging question in the setting of no solid guidelines. Enrollment in clinical trials, if available, would be highly recommended. Otherwise, decision to use a radiosensitizer agent in this space has to be in a multi-D setting discussion with a radiation oncologist who is very fami...