Would you refer a patient for kidney only or kidney and liver transplantation if they develop advanced chronic kidney disease secondary to primary hyperoxaluria type 2?  

Now that the data suggesting a benefit for nedosiran for PH2 is very disappointing, I think we have to say simultaneous liver and kidney. I have this one experience. My PH2 patient had kidney only because I was thinking that nedosiran would be effective. Ultimately, the kidney failed after about 5 y...

We have reasonable experience with kidney and liver transplant in primary hyperoxaluria type 2, and we do believe that it corrects the hyperoxaluria. Thus, in our center, we typically evaluate PH2 patients with kidney failure for potential liver transplantation, especially since the siRNA treatments...