Would you send a gene assay like Mammoprint or Oncotype on a small (<1 cm) lymph node negative lobular infiltrating carcinoma?

I would not, especially if it was low grade and proliferative rate. "Clinical low" patients by MINDACT categorization had excellent prognoses without chemo, although admittedly, this is not specific to patient with lobular histology... Moreover, it is challenging to have enough tissue for a genomic assay with T1a and even a lot of T1b lesions.

If it was close to a centimeter in size and has high risk features (grade 3) - I might try mammaprint. I have found that a lot of ILCs are intermediate o...