Would you still recommend bone marrow biopsy in an elderly non-transplant eligible patient with mild cytopenias if NGS from peripheral blood indicates MDS mutations?

Topics: Hematologic Malignancies • Medical Oncology • Myelodysplastic Syndromes • Hematology

If yes, how does that affect management?

If no, what are your indications for BM biopsy?

Answer from: at Community Practice

Yes. The presence of mutations in peripheral blood is not diagnostic of MDS. The elderly can have CHIP mutations and mild cytopenias which qualify for CCUS rather than MDS. CCUS has a higher risk for progression to MDS but is not MDS by itself. Would get a bone marrow prior to diagnosing MDS and sta...

Comments

Medical Oncologist at Wentworth Douglass Hospital
In patients with LR-MDS in whom supportive care ...

at UMass Chan Medical School
If management is supportive care, you could make...

Medical Oncologist at Wentworth Douglass Hospital
Thank you!

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