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Topics:
Rheumatology • Osteoporosis • Denosumab • Chronic kidney disease • Nephrology • Endocrinology • Bone and Calcium Disorders
Would you stop denosumab in a patient with chronic kidney disease if they develop asymptomatic hypocalcemia after the injection?
Answer from: at Academic Institution
No. Stopping denosumab leads to rebound bone resorption and loss of all gains. The hypocalcemia indicates insufficient calcium and/or calcitriol. Calcium intake should be 1,000-1,200 mg daily from food and/or supplements in divided doses with food.
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