Would you supplement iron for low iron studies in absence of anemia?

The answer is absolutely and positively. Iron deficiency causes symptoms independent of anemia which include fatigue, brain fog, restless legs syndrome, and pagophagia and other forms of pica. You simply cannot dignify waiting for overt iron deficiency to develop in someone with symptomatic iron deficiency. Further, even if asymptomatic, non-anemic iron deficiency is present, it won’t be long before symptoms occur in the overwhelming majority of cases.

If tolerated and with no contraindication to oral iron (inflammatory bowel disease, heavy menstrual bleeding, post-bariatric surgery) one tablet every other day or daily if preferred. However, I have no hesitation whatsoever to use intravenous iron if those conditions are not met.

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Yes, always treat iron deficiency and don't wait for overt anemia to develop. Agree 100% that iron deficiency is associated with a variety of conditions that impact QoL. An additional point, always work up iron deficiency.