Would you treat a patient with HIV or hepatitis C with an anti-PD-1 agent?

Yes, anti-PD-1 agents can be used in patients with HIV or hepatitis C if the viral infection is well controlled. In preclinical studies, PD-1 blockade has been shown to be a promising immunotherapy for HIV and Hepatitis C. This is based on the observation that progressive loss of effector function i...

@Dr. First Last is exactly right. Although all of the larger PD1 and PDL1 trials have excluded HIV+, HCV+ and HBV+ patients, there is little evidence at this time that there are safety concerns with treating a patient with a well-controlled chronic viral infection. Several immunotherapy trials with ...

The Anal Cancer Trial published in Lancet Oncology (april 2015) included HIV positive patients who were compliant with HAART and had an undetectable Viral Load.

The HCC trials also included Hep B/C positive patients as stated above.

There is some thought that the viral infections themselves stimulat...