Would you treat a Stage I ER/PR positive HER2 negative breast cancer differently if it is associated with Lynch syndrome?
Medical Oncologist
In reviewing the literature, there are a number of articles describing the risk of breast cancer in patients with Lynch syndrome such as this: (Nikitin et al., PMID 32547938). The cliff notes are that in patients with Lynch syndrome and certain mutations, there appears to be a small but definite inc...
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Answer from: Radiation Oncologist at Academic Institution
Most germline mutations such as MSH6 (Lynch) involve tumor suppressor genes so it wouldn't be surprising that there is some limited data suggesting an increased risk of a potential RT-induced second malignancy; this speaks to the philosophy of shared decision making but it shouldn't deter a discussi...
Answer from: Radiation Oncologist at Community Practice
Yes, I would treat like any other ER positive patient with breast cancer.