Would you treat endometrioid adenocarcinoma arising from an endometriosis lesion in a patient with prior hyst/BSO like an ovarian or endometrial primary?
Example: in a patient with a non-resectable pelvic mass involving the vagina but without evidence of distant disease, would you favor pelvic RT (as one might do for locoregional non-resectable endometrial) or systemic chemotherapy (as one might do for ovarian)?
Answer from: at Community Practice
For a patient with prior hyst/BSO and now an endometriosis-associated endometrioid adenocarcinoma, I would start by getting next-generation sequencing and MSI/MMR testing of the tissue specimen that was used to make the diagnosis. This would allow for additional information and the potential use of ...
Sign in or Register to read more
Answer from: Radiation Oncologist at Academic Institution
I've seen a few cases where patients with a history of prior TAH for non-oncologic reasons 2+ years earlier developed endometrioid adenocarcinoma of the vaginal cuff, +/- nodal regional disease.
We treat definitively similar to how we would approach vaginal recurrence of endometrial cancer as...
Answer from: at Community Practice
In general, endometrioid adenocarcinomas arising in endometriosis after hysterectomy/BSO are classified as peritoneal carcinomas and are treated like ovarian cancer. Tumor molecular studies may add critical information in directing primary therapy.Background:Numerous epidemiologic studies have demon...