Topics:
Hematologic Malignancies • Pediatric Oncology • Medical Oncology • Bone Marrow Transplant • Leukemia • Cancer Predisposition • Hematology
Would you use a matched sibling donor with a germline heterozygous BRCA1 mutation for stem cell transplant?
Presuming there are no matched unrelated donors.
Answer from: at Community Practice
This is a challenging question due to the lack of clarity around the risk of hematologic cancers in patients who have BRCA1 mutations if patients with Fanconi Anemia are excluded. The role of BRCA haploinsufficiency in marrow hematologic function in otherwise healthy donors is unclear. Multiple stud...
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