Would you use a matched sibling donor with a germline heterozygous BRCA1 mutation for stem cell transplant?

This is a challenging question due to the lack of clarity around the risk of hematologic cancers in patients who have BRCA1 mutations if patients with Fanconi Anemia are excluded. The role of BRCA haploinsufficiency in marrow hematologic function in otherwise healthy donors is unclear. Multiple studies have suggested that in the presence of other marrow stressors that may occur in processes like stem cell transplant, BRCA1 heterozygosity could contribute to poor reconstitution and function. A 20...