Would you use immunotherapy in patients with HIV and a positive viral load?

Current guidelines do not recommend universal HIV screening before starting immune checkpoint inhibitors (ICIs). However, if HIV is known or suspected, patients should ideally be on antiretroviral therapy (ART) before initiating immunotherapy.

Safety:

Retrospective data from the CATCH-IT Consortium (El Zarif et al., PMID 37192435) showed that ICIs are generally safe in people living with HIV, even in those with CD4 <200 cells/µL. In this cohort (viral load <400 copies/mL in 94%), immune-related ad...