Given the equivocal findings of NRG GI003, in which patients would you select for liver-directed proton therapy in the management of HCC?
This question is part of our ASTRO 2026 collaboration, inspired by the Plenary Session Presentation "Initial Results of NRG Oncology NRG-GI003: A Phase III Randomized Trial of Protons vs. Photons for Hepatocellular Carcinoma (HCC)" by Dr. Theodore Hong, MD
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Harvard Medical School.
Answered on
Based on the results presented, there is not an indication to routinely recommend proton-based radiation for HCC. There are ongoing efforts to see if there is a subgroup that benefits from protons.
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