Questions discussed in this category
Is there a minimum time of waiting that is necessary between the completion of cancer treatment and liver transplantation?
Is there an absolute cutoff for AST/ALT that you use where the risks outweigh the potential harm reduction benefits of using the medication? &nbs...
If you prefer monitoring strategy, how frequently do you repeat labs and what is your referral thresholds to hepatology if you're practicing in primar...
Do you prescribe it universally or based on specific risk factors?
Is this a sequential process? Simultaneous?
At what point do you feel comfortable using diuretics or performing a therapeutic paracentesis?
Is there such a thing as "too early" referral? How can we best utilize the time and resources of a liver transplant center for such patients?
Do you tackle the alcohol first over the metabolic comorbidities?
Most antibiotics used to treat the H. pylori are contraindicated in cirrhosis.
Is a liver mass a presentation of IgG4 related disease?
What should be ordered? Any medications given?
What are your management/preventative strategies, and are they specific to your experiences and/or institution?
Do you opt for "accepting" a higher creatinine and worsening renal dysfunction for more euvolemia? How would this change your practice if a patient wa...
How would this value impact your subsequent management?
For example, anticoagulation for recent, significant PE or dual antiplatelet therapy for recent MI, but requiring urgent procedures such as biopsy of ...
In general, for which malignancy would this most commonly be entertained and what patient criteria would make them an optimal candidate?
Would treating underlying cirrhosis/transplant cure the driver of their cardiac dysfunction, and is this reversible? What unique transplant complicati...
What other patient factors and nuances do you take into consideration in patient selection and use of specific perfusion options (ex: normothermic vs....
For example, what do you do when someone requests aggressive, life-prolonging treatments but then is not receptive to elements of day-to-day care in t...
Do you opt for dose reduction? Switching medications?
Do you use TEG or ROTEM? How do you counsel proceduralists on the unique hemostatic profile of patients with cirrhosis?
What findings would suggest to you that a patient has a pre-core mutant?
How do you go about working up and managing patients with these findings?
Patient is undergoing RT and has already started on a GnRH antagonist. If so, how long after their last fraction would be an appropriate wait time?
(Ex: cholecystectomy, orthopedic surgery, etc.)
What clinical, system, and/or social factors play into this decision?
How do factors like the presence of varices, severity of coagulopathy, etc., play into your decision?
Do you perform any subsequent testing?
And what would be your choice?
Do you find risk scores such as VOCAL-Penn to be helpful?
Does your practice differ depending on the disease site?
Are there situations in which you would continue the possible offending agent with close monitoring?
Patient with extrahepatic cholangiocarcinoma s/p Whipple in 2021 with negative margins and no positive nodes followed by adjuvant chemo with subsequen...
What are you looking for that would impact your management of a patient?
Data are scattered, with some starting concurrent and some starting after SBRT to optimize the priming of the immune system with RT.
How would your recommendation change if the patient has H63 homozygous mutation?
What kind of patient would be an ideal recipient of such an organ?
For example, someone needing a higher platelet count for dual antiplatelet agent use after coronary stent placement.
I have several forensic patients who have elevated LFTs and fatty liver on ultrasound, at least in part due to long-term olanzapine use. They are all ...
Any management considerations with respect to disease etiology?
For example, would you consider alternatives to paracentesis (Denver shunt placement, CART therapy, or permanent tunneled catheters) that might better...
Given the improvement in liver function, what factors should be considered before reinitiating immunotherapy?"
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Papers discussed in this category
The New England journal of medicine, 1987-03-05
Hepatology (Baltimore, Md.), 2018 Apr
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020 Dec 31
Journal of viral hepatitis, 2019 Dec 22
Topics in antiviral medicine, 2023 Mar 31
Journal of acquired immune deficiency syndromes (1999), 2023 Oct 01
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024 Mar 19
Hepatology (Baltimore, Md.), 2023 May 22
Hepatology research : the official journal of the Japan Society of Hepatology, 2025 Jan 15
Investigational new drugs, 2024 Aug 30
Lancet (London, England), 2015-03-14
The New England journal of medicine, 2020 Nov 13
Gastroenterology, 2015 Apr 10
The New England journal of medicine, 2010 Apr 28
Hepatology (Baltimore, Md.), 2022 Jan 24
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021 Jun 04
The New England journal of medicine, 2024 Feb 08
Hepatology (Baltimore, Md.), 2024 Oct 18
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020 Oct 23
Clinical journal of the American Society of Nephrology : CJASN, 2023 Oct 17
International journal of molecular sciences, 2022 Mar 13
Radiother Oncol, 2017 May
Hepatology (Baltimore, Md.), 2012 Apr
The New England journal of medicine, 2021 Mar 04
Archives of internal medicine, 2006 Feb 13
Cancer chemotherapy and pharmacology, 2019 Aug 23
Hepatology (Baltimore, Md.), 2022 Dec 07
The American journal of gastroenterology, 2024 Jan 26
The American journal of gastroenterology, 2024 Oct 21
Gastroenterology, 2009-09
European journal of endocrinology, 2023 Aug 02
JAMA oncology, 2017-04-01
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018-05
Transplant international : official journal of the European Society for Organ Transplantation, 2021 Nov 22
Cardiovascular and interventional radiology, 2024 Jun 10
Drug and alcohol dependence, 2024 Sep 07
JAMA psychiatry, 2025 Apr 01
Gastroenterology, 2018 May 17
The New England journal of medicine, 2012 Aug 23
Medicine, 2016 Jan
Clinical nephrology, 2011 Oct
The American journal of medicine, 1992 Jul
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002 Jul
The New England journal of medicine, 2024 Jul 25
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-05-20
Hepatology (Baltimore, Md.), 2023 Oct 23
The New England journal of medicine, 2021 Mar 04
Gastroenterology, 2025 Feb
Lancet Haematol, 2018 Oct
JHEP reports : innovation in hepatology, 2024 Apr 10
Hepatology (Baltimore, Md.), 2012-01
Clinical and translational gastroenterology, 2019 Apr
Journal of thrombosis and haemostasis : JTH, 2010 Nov
Journal of thrombosis and haemostasis : JTH, 2022 Aug 10
Techniques in vascular and interventional radiology, 2016-03
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2022 Jun 16
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2025 Aug 22
Hepatology (Baltimore, Md.), 2021 Jan 20