How do you decide which patients should pursue add-on bepirovirsen rather than continue indefinite nucleos(t)ide analogue monotherapy for noncirrhotic chronic HBV?

1. HBsAg quantitation to determine if they meet criteria
2. Frank discussion that only 1 in 5 patients succeed and that the 6-month weekly injections do have a relatively high rate of significant adverse hematological and renal complications requiring close laboratory monitoring.

So far, most patients h...