What infectious prophylaxis would you recommend in an infant with Wiskott-Aldrich syndrome during donor search and pre-transplant?

In infants with Wiskott-Aldrich syndrome, the degree of immune deficiency is variable and should be evaluated with a comprehensive assessment of both T-cell and B-cell immunity. Current testing typically includes lymphocyte subsets (CD3, CD4, CD8, CD19/20, NK cells), quantitative immunoglobulins (IgG, IgA, IgM, IgE), assessment of vaccine antibody responses when applicable, naïve/memory T-cell phenotyping, lymphocyte proliferation assays to mitogens/antigens, and molecular confirmation of the WAS gene mutation. Because these infants are highly vulnerable to viral infections before hematopoietic stem cell transplantation, careful screening for prior viral exposure is important, particularly for herpesviruses such as CMV, EBV, HSV, VZV, and H...