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After progression on osimertinib, do you recommend overlapping TKI with 2nd line chemotherapy to avoid accelerated disease progression?
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1 AnswersMednet Member
Medical Oncology · Indiana University
I do not continue the EGFR TKI in patients once clear evidence of clinical and radiologic progression makes me recommend a switch from an EGFR TKI to chemotherapy. This approach is considered due to reports regarding the potential tumor flare phenomena noted upon discontinuation of EGFR TKIs. There ...