Mednet Logo

After progression on osimertinib, do you recommend overlapping TKI with 2nd line chemotherapy to avoid accelerated disease progression?

Retrospective data suggest clinically significant disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer during washout periods before starting new treatment.
Community PollStarted

Do you recommend overlapping TKI with 2nd line chemotherapy (or chemo-IO) for EGFR+ NSCLC to avoid accelerated disease progression after progression on TKI?

59 physicians have voted

Join Mednetto vote and see how they answered.

1 Answer
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Indiana University
Answered on

I do not continue the EGFR TKI in patients once clear evidence of clinical and radiologic progression makes me recommend a switch from an EGFR TKI to chemotherapy. This approach is considered due to reports regarding the potential tumor flare phenomena noted upon discontinuation of EGFR TKIs. There ...

Join for free or sign in to see the full answer