Are the results of the SEAM-RA trial generalizable to other TNF inhibitors given the differences in immunogenicity?

Withdrawal of methotrexate may lead to more disease flares and lack of recoverability with other TNF inhibitors.

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Given the results of the SEAM-RA trial, are you more likely to attempt withdrawal of methotrexate in patients on any TNF inhibitor?

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1 Answer

Mednet Member

Rheumatology · University of Alabama

Answered on

This is a great question, and an important one because different TNF inhibitors have different immunogenicity and patients can make anti-drug antibodies that can effectively neutralize the drug and render it a less effective treatment option. This tends to happen more with some molecular constructs ...

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