What was the rationale for abrupt discontinuation of etanercept rather than gradual tapering in the SEAM-RA trial?
The ACR 2021 RA Guidelines suggest the gradual tapering approach is preferable.
Community PollStarted
Given the results of the SEAM-RA trial, are you more likely to consider abrupt withdrawal of medication as opposed to gradual discontinuation?
15 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet Member
Rheumatology · University of Alabama
Answered on
The main goal of this trial was to get RA patients off of therapy and to see whether they would flare or maintain remission. We didn’t expect that the ultimate likelihood of success or failure was going to be primarily related to how long it took to do that. While a gradual withdrawal of the drug ma...
Join for free or sign in to see the full answer
Mednet Member
Rheumatology · John D. Dingell VA Medical Center
Answered on
I would taper Methotrexate first.
Join for free or sign in to see the full answer