Are there circumstances when you would consider re-irradiation of the esophagus in a patient who is not a surgical candidate or declines surgery?

Reirradiation of the esophagus is something that comes up infrequently, but consistently in esophageal cancer patients treated with radiation. There are multiple specific scenarios, with various levels of risk. There are multiple options available, and there is not prospective data comparing these o...

Re-irradiation of the chest has been specifically studied by MD Anderson in a 2018 PRO journal paper using Intensity Modulated Proton Therapy (IMPT). 81% of patients had lung cancer, but it should be applicable to the esophagus.

They showed that re-treatment with proton doses of 66 Gy or more was fea...