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Are there instances where you can defer on mass spectrometry testing for amyloid typing in Congo Red positive tissue?
For instance, if Congo Red positivity is also noted in bone marrow biopsy along with immunofluorescence concerning for AL amyloidosis.
Answer from: Medical Oncologist at Academic Institution
This is a great question and one that is not uniform in its answer depending on the clinical situation.Assuming we are talking about at diagnosis here, the short answer is always send Congo red positive bone marrow findings for mass spec typing if there is enough positive protein to dissect and type...
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