Are there specific findings that would make you suspicious of IgD or IgE monoclonal gammopathies?
For instance, SPEP with possible restriction, though serum immunofixation negative, and elevated light chain ratio.
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Medical Oncology · Hosp of the Univ of Pennsylvania
Answered on · Updated on
I mostly consider an IgD or IgE monoclonal gammopathy in a patient who has a measurable serum M-spike on serum protein electrophoresis but a serum immunofixation that only shows a light chain band (either kappa or lambda). Since patients with light chain-only myeloma usually have at most a tiny mono...
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