Are there specific findings that would make you suspicious of IgD or IgE monoclonal gammopathies?
For instance, SPEP with possible restriction, though serum immunofixation negative, and elevated light chain ratio.
Answer from: Medical Oncologist at Academic Institution
I mostly consider an IgD or IgE monoclonal gammopathy in a patient who has a measurable serum M-spike on serum protein electrophoresis but a serum immunofixation that only shows a light chain band (either kappa or lambda). Since patients with light chain-only myeloma usually have at most a tiny mono...