Are you comfortable combining relugolix with enzalutamide or abiraterone?

I usually avoid these combinations. The challenge is that relugolix is not superior to other ADT methods in terms of efficacy (at least based on available data) but there are safety issues with considering these combinations. All three of these medications are substrates for similar enzymatic metabo...

A phase I study testing the combination of relugolix and abiraterone or apalutamide showed favorable safety and tolerability profile. The effects on the levels of testosterone were also maintained after transitioning from other ADTs to relugolix (De La Cerda et al., PMID 37060432).

The The REAL-ADT ...