Please select the option that best describes you:
Topics:
Rheumatology • Systemic lupus erythematosus
Are you comfortable using belimumab in patients with a history of significant depression?
How do you go about counseling the patient? What type of additional history do you obtain to assess risk?
Answer from: at Academic Institution
If the patient has depression on treatment with control or a history of depression, I discuss the potential risk of belimumab possibly making it worse. I discuss with them that they need to let me know and their PCP or mental health professional if they note a change in their mood and/or developing ...
Sign In or Register to read more
Answer from: at Community Practice
Initial RCTs for belimumab in non-renal SLE surprisingly showed an association with this drug and increased risk of depression, leading to a black box warning on FDA prescribing instructions. Subsequent studies and meta-analyses have further evaluated this risk, which show a modest increased risk of...