For what sort of SLE clinical profile do you favor anifrolumab beyond patients with prominent skin manifestations?  

Skin disease is obviously the primary clinical manifestation. I will also prescribe it to patients with arthritis, pericarditis, mucosal disease, and hair loss. I await the results of the trial in lupus nephritis. I have an n of 1 experience with a patient with long-term high anti-dsDNA and low comp...

I would consider using anifrolumab in patients with active non-renal SLE, including arthritis (acknowledging limited impact on joint counts in RCT), alopecia, oral/nasal ulcers, serositis, etc. I have sometimes found it helpful in my practice to check for an interferon signature if I am debating whe...