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Besides GI evaluation and testing for celiac, what other testing do you consider with a patient with unexplained Iron deficiency anemia and a negative bleeding history?

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Beyond EGD/colonoscopy and celiac disease testing, what additional diagnostic evaluation do you consider in patients with unexplained iron deficiency anemia and no identifiable source of blood loss?

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1 Answer
Mednet MemberInvited Expert
Hematology · Georgetown University School of Medicine
Answered on

I assume this question comes after endoscopies are negative. Autoimmune gastritis is 30 times more frequent that celiac. So anti-parietal cell antibody should be ordered. >30 likely, >50 usually diagnostic. If still negative a history of long duration therapy for reflux will explain iron deficiency ...

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