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Can docetaxel be safely given to patients with hyperbilirubinemia from Gilbert’s syndrome?

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Medical Oncology · Avita Health System
Answered on

Docetaxel can be safely administered at full doses in patients with Gilbert's Syndrome. These patients usually have a variant in the UGT1A1 gene. While it can cause issues with some oncologic therapies (especially ones that rely on UGT-1A - the classic being irinotecan), it does not seem to affect t...

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