HomeQuestion
Can docetaxel be safely given to patients with hyperbilirubinemia from Gilbert’s syndrome?
1 Answers
Mednet Member
Medical Oncology · Avita Health System
Docetaxel can be safely administered at full doses in patients with Gilbert's Syndrome. These patients usually have a variant in the UGT1A1 gene. While it can cause issues with some oncologic therapies (especially ones that rely on UGT-1A - the classic being irinotecan), it does not seem to affect t...