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What imaging surveillance for ILD do you utilize for patients with HER2+ breast cancer receiving adjuvant T-DXd?

Is your imaging surveillance similar to metastatic patients?
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What imaging do you use for ILD surveillance in patients on adjuvant T-DXd?

5 physicians have voted

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3 Answers
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Medical Oncology · University of Kansas Medical Center
Answered on

I follow the protocol as described in DESTINY-Breast05 (Loibl et al., PMID 41370739):

For patients who received adjuvant radiotherapy, monitoring for asymptomatic or mildly symptomatic therapy-related interstitial lung disease or pneumonitis included serial low-dose CT of the chest at 6 weeks after t...

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Medical Oncology · UC Irvine Health/Chao Family Comprehensive Cancer Center
Answered on

I utilize high-resolution CT (HRCT) of the chest to monitor patients receiving adjuvant T-Dxd. Per DESTINY-Breast05, a protocol mandate, ILD surveillance with low-dose non-contrast (LDCT) was done at baseline and 6 weeks, followed by every 12 weeks during treatment and 6 weeks post-therapy completio...

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Medical Oncology · H Lee Moffitt Cancer Center, University of South Florida
Answered on

I would follow the protocol for the 1st scan at 6 weeks, then every 12 weeks thereafter.

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