Can tacrolimus in a transplant patient be used during radiation and concurrent chemoradiation?

Patients with solid organ transplants present unique challenges in management and risk of infectious complications, among others. The short answer is that tacrolimus can be used in the lowest dose possible, along with concurrent chemoradiation and close coordination with the transplant team. If the tumor is resectable, then surgery would be a preferred option to chemoradiation. Due to the chronic immunosuppression, these tumors tend to be more treatment-resistant.