Can tamoxifen be safely prescribed for breast cancer patients with cirrhosis?

Tamoxifen would definitely not be my preferred endocrine agent in a patient with cirrhosis. I have had many cases of tamoxifen-induced liver injury. The incidence of MASH due to tamoxifen is really underreported in the literature. In a case of pre-existing MASH or other liver disease, I switch to an...

In my experience, tamoxifen can be prescribed for patients with cirrhosis/liver disease safely (since liver toxicity of tamoxifen, while possible, is uncommon). Generally, when I start a patient with liver disease on tamoxifen, I communicate with their hepatologist ahead of time about my plans for t...

I think the key question here is what tamoxifen is being prescribed for, and what is the balance of benefit vs toxicity and competing comorbidities.

Is tamoxifen being prescribed for DCIS after lumpectomy, or is it for metastatic disease? If it is for adjuvant treatment of invasive disease, then it ...

Although tamoxifen may be safely used in patients with liver disease, I would be cautious in using it in patients with Child-Pugh C and above, as there is no data.