Can you safely proceed with breast irradiation during treatment with immunotherapy?

In KEYNOTE-522, RT was done with concurrent Pembro after NACT plus IO and no significant additional untoward effect was reported. So, we do RT routinely with Pembro for these patients.

I agree with Dr. @Dr. First Last's response. In my clinical practice, I also routinely proceed with adjuvant RT during the adjuvant immunotherapy portion of these patients' treatment. I do discuss the exceedingly low risk of radiation pneumonitis with these patients (not outside of my usual clinical...