Geriatric Medicine

Neuro-immunology

Questions discussed in this category

How do you approach a mildly positive finding on an autoimmune encephalitis panel when there is no other evidence of encephalitis (such as elevated CSF protein, abnormal imaging, or EEG findings)?

For example, a GAD65 Ab of 0.07 when the cut-off is 0.02. Does this answer change if you consider adult vs pediatric populations?

2 Answers available

What is your approach to checking serum vWF antigen levels in adult patients with CNS vasculitis for monitoring disease activity?

Small study in pediatric PACNS have evaluated this as a potential marker (Cellucci et al., PMID 22740622)

1 Answer available

Papers discussed in this category

Archives of neurology, 2009-06

Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments.

Muscle & nerve, 2013-04

Striational antibodies in a paraneoplastic context.

Muscle & nerve, 2016-08

P/Q- and N-type calcium-channel antibodies: Oncological, neurological, and serological accompaniments.

Muscle & nerve, 2017-07

GAD65 neurological autoimmunity.

Annals of neurology, 2017-07

Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients.

Front Neurol, 2019 Jun 06

Primary Angiitis of the Central Nervous System: New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid.

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