Hematologic Malignancies

Nephrology

Questions discussed in this category

When MGUS is suspected in a patient with one risk factor and no evidence of end-organ damage, what additional workup should be done, if any?

Risk factors include: non-IgG subtype, abnormal serum light chain ratio, M-protein >=1.5 mg/dL. Further work up could include imaging, bone marrow...

1 Answer available

How would you approach management and monitoring of AL amyloidosis with isolated renal involvement?

AL amyloid biopsy proven on renal biopsy. Normal SPEP and FLC, bone marrow biopsy with 10-15% plasma cells.

2 Answers available

In which patients with MGUS do you recommend a kidney biopsy to evaluate for MGRS?

2 Answers available

How do you approach treatment for patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) with end-stage renal disease who are considering kidney transplant?

Most patients with PGNMID have no detectable disease in their marrow or blood and urine protein cannot adequately be monitored.

1 Answer available

How would you approach post-operative VTE prophylaxis for renal transplant in patients with a prior history of provoked VTE?

Are there specific guidelines for managing this patient population?

1 Answer available

How do you monitor multiple myeloma in patients receiving dialysis?

Since free light chains are removed by dialysis and SPEP can also be impacted, is there a reliable way to monitor patients with ESRD and MM?

1 Answer available

How is monoclonal gammopathy of renal significance (MGRS) different from myeloma kidney?

If there are light chain deposits on the kidney, is that conclusive of MGRS?

1 Answer available

What is your preferred first line regimen for myeloma with severe renal impairment, either on or off dialysis?

1 Answer available

Would you consider giving ESA for anemia secondary to chronic kidney disease in a patient with follicular lymphoma in remission and on rituximab maintenance?

1 Answer available

Papers discussed in this category

The New England journal of medicine, 2024 Dec 09

Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma.

European journal of haematology, 2013 Aug 17

Monoclonal gammopathy of undetermined significance: a new proposal of workup.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2021 Dec 06

Antithrombotic Management in Adult Kidney Transplantation: A European Survey Study.

Kidney international, 2018-07

Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft.

BMC nephrology, 2019-02-14

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2019 Oct 09

The utility of repeat kidney biopsy in systemic immunoglobulin light chain amyloidosis.

N Engl J Med,

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.

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